Talk:Safrole

Carceinogenicity

Limonene (in orange juice) and caffeic acid (in tomatoes) are concidered benneficial anti-cancer foods. So, is safrole similar to them or opposite? — Preceding unsigned comment added by 74.247.199.50 (talk) 16:59, 14 November 2011 (UTC)[reply]

This page [1] suggests that "safrol" is the same compound as "safrole". Is it? -- The Anome 21:52, 6 Oct 2004 (UTC)

74.247.199.50, There are recent studies that actually suggest it has anti cancer benefits rather than causing cancer: Safrole Induces Apoptosis in Human Oral Cancer HSC-3 Cells Ittiz (talk) 16:22, 15 June 2013 (UTC)[reply]

It doesnt need to

Please think about it. Safrole weighs 162.188 g/mol and has a molecular formula C10H10O2.

Microswitch 04:59, 27 January 2007 (UTC)[reply]

External Links

I'm removing http://monographs.iarc.fr/htdocs/monographs/vol10/safrole.html from the external links because its broken. Jawareham 12:42, 22 April 2007 (UTC)[reply]

The link to http://monographs.iarc.fr/ENG/Monographs/vol10/volume10.pdf seems to not be broken today. 67.86.73.252 (talk) 12:46, 19 April 2008 (UTC)[reply]

Reference

Robinson Percy Foulds and Robert Robinson (1914). "Some derivatives of safrole". J. Chem. Soc., Trans. 105: 1963. doi:10.1039/CT9140501963.--Stone 16:34, 14 June 2007 (UTC)[reply]

Safrole in black pepper

Some sources state that safrole is contained in black pepper. This should be added to the article. Badagnani (talk) 03:41, 12 December 2007 (UTC)[reply]

It looks like it isn't particularly abundant in black pepper oil from a quick search. Black, Black & White pepper at 0.52% or less, White pepper at 2.98% (although that was using a "scent analysis" technique that involves air sampling followed by GC/MS in one paper testing pepper varieties specific to Cameroon. Other journals that analyzed don't even list it... This one doesn't list it at all, nor do most I can find. The black pepper page on Wikipedia does list it, but doesn't have a reference listed. They Terk Err Jerbs (talk) 14:21, 14 May 2016 (UTC)[reply]

Smell of Safrole

Although I don't think there is a way to prove what a molecule smells like, I can attest to the following: sassafras bark has a smell more reminiscent of coca cola than modern day rootbeer. Sassafras oil has an initial clean cola scent followed by a somewhat rancid wood mulch smell. I think safrole is the first note and various impurities are the second note. I have never smelled pure safrole, but I think the smell of sassafras bark is probably the best representation. Source: I live in an area of Pennsylvania where Sassafras albidum is endemic. I have also seen it distilled. Sorry I can't be more scientific. — Preceding unsigned comment added by 2607:FB90:315:9A69:0:8:B03D:D501 (talk) 21:47, 15 December 2014 (UTC)[reply]

Sassafras oil redirects here?

Have been trying to clean up the List of essential oils page and add references where possible, make it more navigable, etc, and noticed that "Sassafras oil" redirects to this page. Although it is a primary constituent of that oil, the same could be said for many other plant oils. Is this really correct? I may be missing a discussion somewhere, but haven't found one. In some bizarre irony, the Sassafras page has a section entitled "Safrole oil". Just wondering if that redirect should actually exist, an essential oil and a pure chemical aren't really the same thing at all. They Terk Err Jerbs (talk) 09:45, 14 May 2016 (UTC)[reply]

Seems a valid argument to me, but I haven't checked current status of redirects.

Piggybacking (my mobile doesn't recognize the 'New Section' button), why is safrole described as a phenylpropanol? I don't see a propanol moiety; the side-chain has no OH. No doubt there are historical reasons; I haven't yet followed up the sources. But it looks to me at first glance more like a terpenoid. It's a small point, but if supported by good sources it needs a little explanation. This article evidently is mature & doesn't get much attention; I'm putting it on my Watchlist & MAY get around to some digging. --D Anthony Patriarche, BSc (talk) 14:44, 21 August 2020 (UTC)[reply]

Sorry, my eyes betrayed me; I see it is actually described as a phenylpropanoid; the wikilink explains it, tho as a chemist I still find the nomenclature a bit odd & confusing. --D Anthony Patriarche, BSc (talk) 14:58, 21 August 2020 (UTC)[reply]

Potential source

French, Larry G. (June 1995). "The Sassafras Tree and Designer Drugs: From Herbal Tea to Ecstasy". Journal of Chemical Education. 72 (6): 484. doi:10.1021/ed072p484. Sizeofint (talk) 02:48, 10 January 2017 (UTC)[reply]

Natural Occurrence Section Duplicate

The final paragraph in the "Natural Occurrence" section is mostly just a rewrite/duplicate of the above paragraphs. One or the other should be removed and edited. Baconaetor (talk) 16:38, 13 March 2023 (UTC)[reply]